Two-Dimensional Electrophoresis of Tau Mutants Reveals Specific Phosphorylation Pattern Likely Linked to Early Tau Conformational Changes

The role of Tau phosphorylation in neurofibrillary degeneration linked to Alzheimer's disease remains to be established. While transgenic mice based on FTDP-17 Tau mutations recapitulate hallmarks of neurofibrillary degeneration, cell models could be helpful for exploratory studies on molecular...

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Detalhes bibliográficos
Main Authors: Bretteville, Alexis, Ando, Kunie, Ghestem, Antoine, Loyens, Anne, Bégard, Séverine, Beauvillain, Jean-Claude, Sergeant, Nicolas, Hamdane, Malika, Buée, Luc
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653646/
https://ncbi.nlm.nih.gov/pubmed/19290042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004843
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