DNA Methylation Analysis of Chromosome 21 Gene Promoters at Single Base Pair and Single Allele Resolution

Differential DNA methylation is an essential epigenetic signal for gene regulation, development, and disease processes. We mapped DNA methylation patterns of 190 gene promoter regions on chromosome 21 using bisulfite conversion and subclone sequencing in five human cell types. A total of 28,626 subc...

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Detalhes bibliográficos
Main Authors: Zhang, Yingying, Rohde, Christian, Tierling, Sascha, Jurkowski, Tomasz P., Bock, Christoph, Santacruz, Diana, Ragozin, Sergey, Reinhardt, Richard, Groth, Marco, Walter, Jörn, Jeltsch, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653639/
https://ncbi.nlm.nih.gov/pubmed/19325872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000438
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