Genistein-mediated inhibition of glycosaminoglycan synthesis, which corrects storage in cells of patients suffering from mucopolysaccharidoses, acts by influencing an epidermal growth factor-dependent pathway

BACKGROUND: Mucopolysaccharidoses (MPS) are inherited metabolic disorders caused by mutations leading to dysfunction of one of enzymes involved in degradation of glycosaminoglycans (GAGs). Due to their impaired degradation, GAGs accumulate in cells of patients, which results in dysfunction of tissue...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jakóbkiewicz-Banecka, Joanna, Piotrowska, Ewa, Narajczyk, Magdalena, Barańska, Sylwia, Węgrzyn, Grzegorz
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2009
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653532/
https://ncbi.nlm.nih.gov/pubmed/19272193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-16-26
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