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Conformational Flexibility of Metazoan Fatty Acid Synthase Enables Catalysis

The metazoan cytosolic fatty acid synthase (FAS) contains all of the enzymes required for de novo fatty acid biosynthesis covalently linked around two reaction chambers. While the 3D architecture of FAS has been mostly defined, it is unclear how reaction intermediates can transfer between distant ca...

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Detalhes bibliográficos
Main Authors: Brignole, Edward J., Smith, Stuart, Asturias, Francisco J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653270/
https://ncbi.nlm.nih.gov/pubmed/19151726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1532
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