Blastocyst Injection of Wild Type Embryonic Stem Cells Induces Global Corrections in Mdx Mice

Duchenne muscular dystrophy (DMD) is an incurable neuromuscular degenerative disease, caused by a mutation in the dystrophin gene. Mdx mice recapitulate DMD features. Here we show that injection of wild-type (WT) embryonic stem cells (ESCs) into mdx blastocysts produces mice with improved pathology...

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Bibliografische gegevens
Hoofdauteurs: Stillwell, Elizabeth, Vitale, Joseph, Zhao, Qingshi, Beck, Amanda, Schneider, Joel, Khadim, Farah, Elson, Genie, Altaf, Aneela, Yehia, Ghassan, Dong, Jia-hui, Liu, Jing, Mark, Willie, Bhaumik, Mantu, Grange, Robert, Fraidenraich, Diego
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2009
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653195/
https://ncbi.nlm.nih.gov/pubmed/19277212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004759
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