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Corin Variant Associated with Hypertension and Cardiac Hypertrophy Exhibits Impaired Zymogen Activation and Natriuretic Peptide Processing Activity

Corin is a cardiac serine protease that acts as the pro-atrial natriuretic peptide (ANP) convertase. Recently, two single nucleotide polymorphisms (SNPs) (T555I and Q568P) in the human corin gene have been identified in genetic epidemiological studies. The minor I555/P568 allele, which is more commo...

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Библиографические подробности
Главные авторы: Wang, Wei, Liao, Xudong, Fukuda, Koichi, Knappe, Sabine, Wu, Faye, Dries, Daniel L., Qin, Jun, Wu, Qingyu
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652846/
https://ncbi.nlm.nih.gov/pubmed/18669922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.177352
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