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The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome
Although HEF1 has a well-defined role in integrin-dependent attachment signaling at focal adhesions, it relocalizes to the spindle asters at mitosis. We report here that overexpression of HEF1 causes increase in centrosome numbers and multipolar spindles, resembling defects induced by manipulation o...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652766/ https://ncbi.nlm.nih.gov/pubmed/16184168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1309 |
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