IMATINIB MESYLATE INHIBITS FIBROGENESIS IN ASBESTOS-INDUCED INTERSTITIAL PNEUMONIA

Profibrogeneic cytokines contribute to the accumulation of myofibroblasts in the lung interstitium in idiopathic pulmonary fibrosis (IPF). Imatinib mesylate, a tyrosine kinase inhibitor specific for Abl, platelet-derived growth factor receptor (PDGFR) and c-Kit tyrosine kinases, has been shown to in...

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Bibliographic Details
Main Authors: Vuorinen, Kirsi, Gao, Fei, Oury, Tim D., Kinnula, Vuokko L., Myllärniemi, Marjukka
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652685/
https://ncbi.nlm.nih.gov/pubmed/17849262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/01902140701634827
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