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Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu

The HIV-1 Vpu protein is required for efficient viral release from human cells. For HIV-2, the envelope (Env) protein replaces the role of Vpu. Both Vpu and HIV-2 Env enhance virus release by counteracting an innate host-cell block within human cells that is absent in African green monkey (AGM) cell...

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Detalhes bibliográficos
Main Authors: Varthakavi, Vasundhara, Heimann-Nichols, Ellen, Smith, Rita M, Sun, Yuehui, Bram, Richard J, Ali, Showkat, Rose, Jeremy, Ding, Lingmei, Spearman, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652483/
https://ncbi.nlm.nih.gov/pubmed/18500349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm1778
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