Calprotectin S100A9 Calcium-binding Loops I and II Are Essential for Keratinocyte Resistance to Bacterial Invasion

Epithelial cells expressing calprotectin, a heterodimer of S100A8 and S100A9 proteins, are more resistant to bacterial invasion. To determine structural motifs that affect resistance to bacterial invasion, mutations were constructed in S100A9 targeting the calcium-binding loops I and II (E36Q, E78Q,...

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Détails bibliographiques
Auteurs principaux: Champaiboon, Chantrakorn, Sappington, Kaia J., Guenther, Brian D., Ross, Karen F., Herzberg, Mark C.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Molecular Basis of Cell and Developmental Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652321/
https://ncbi.nlm.nih.gov/pubmed/19122197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806605200
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