The Roles of Selected Arginine and Lysine Residues of TAFI (Pro-CPU) in Its Activation to TAFIa by the Thrombin-Thrombomodulin Complex

Thrombomodulin (TM) increases the catalytic efficiency of thrombin (IIa)-mediated activation of thrombin-activable fibrinolysis inhibitor (TAFI) 1250-fold. Negatively charged residues of the C-loop of TM-EGF-like domain 3 are required for TAFI activation. Molecular models suggested several positivel...

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Detalhes bibliográficos
Main Authors: Wu, Chengliang, Kim, Paul Y., Manuel, Reg, Seto, Marian, Whitlow, Marc, Nagashima, Mariko, Morser, John, Gils, Ann, Declerck, Paul, Nesheim, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Enzyme Catalysis and Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652281/
https://ncbi.nlm.nih.gov/pubmed/19074424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804745200
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