Constitutively Activated ALK2 and Increased SMAD1/5 Cooperatively Induce Bone Morphogenetic Protein Signaling in Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by congenital malformation of the great toes and by progressive heterotopic bone formation in muscle tissue. Recently, a mutation involving a single amino acid substitution in a bone morphogenetic protein...

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Bibliographic Details
Main Authors: Fukuda, Toru, Kohda, Masakazu, Kanomata, Kazuhiro, Nojima, Junya, Nakamura, Atsushi, Kamizono, Jyunji, Noguchi, Yasuo, Iwakiri, Kiyofumi, Kondo, Takeo, Kurose, Junichi, Endo, Ken-ichi, Awakura, Takeshi, Fukushi, Junichi, Nakashima, Yasuharu, Chiyonobu, Tomohiro, Kawara, Akira, Nishida, Yoshihiro, Wada, Ikuo, Akita, Masumi, Komori, Tetsuo, Nakayama, Konosuke, Nanba, Akira, Maruki, Yuichi, Yoda, Tetsuya, Tomoda, Hiroshi, Yu, Paul B., Shore, Eileen M., Kaplan, Frederick S., Miyazono, Kohei, Matsuoka, Masaru, Ikebuchi, Kenji, Ohtake, Akira, Oda, Hiromi, Jimi, Eijiro, Owan, Ichiro, Okazaki, Yasushi, Katagiri, Takenobu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Molecular Basis of Cell and Developmental Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652274/
https://ncbi.nlm.nih.gov/pubmed/18684712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801681200
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