Auto-Ubiquitination-Induced Degradation of MALT1-API2 Prevents BCL10 Destabilization in t(11;18)(q21;q21)-Positive MALT Lymphoma

BACKGROUND: The translocation t(11;18)(q21;q21) is the most frequent chromosomal aberration associated with MALT lymphoma and results in constitutive NF-κB activity via the expression of an API2-MALT1 fusion protein. The properties of the reciprocal MALT1-API2 were never investigated as it was repor...

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Bibliographic Details
Main Authors: Noels, Heidi, Somers, Riet, Liu, Hongxiang, Ye, Hongtao, Du, Ming-Qing, De Wolf-Peeters, Christiane, Marynen, Peter, Baens, Mathijs
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652110/
https://ncbi.nlm.nih.gov/pubmed/19279678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004822
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