An African Ancestry-Specific Allele of CTLA4 Confers Protection against Rheumatoid Arthritis in African Americans

Cytotoxic T-lymphocyte associated protein 4 (CTLA4) is a negative regulator of T-cell proliferation. Polymorphisms in CTLA4 have been inconsistently associated with susceptibility to rheumatoid arthritis (RA) in populations of European ancestry but have not been examined in African Americans. The pr...

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Main Authors: Kelley, James M., Hughes, Laura B., Faggard, Jeffrey D., Danila, Maria I., Crawford, Monica H., Edberg, Yuanqing, Padilla, Miguel A., Tiwari, Hemant K., Westfall, Andrew O., Alarcón, Graciela S., Conn, Doyt L., Jonas, Beth L., Callahan, Leigh F., Smith, Edwin A., Brasington, Richard D., Allison, David B., Kimberly, Robert P., Moreland, Larry W., Edberg, Jeffrey C., Bridges, S. Louis
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652071/
https://ncbi.nlm.nih.gov/pubmed/19300490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000424
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