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Comparative kinomics of human and chimpanzee reveal unique kinship and functional diversity generated by new domain combinations
BACKGROUND: Phosphorylation by protein kinases is a common event in many cellular processes. Further, many kinases perform specialized roles and are regulated by non-kinase domains tethered to kinase domain. Perturbation in the regulation of kinases leads to malignancy. We have identified and analys...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
BioMed Central
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2651890/ https://ncbi.nlm.nih.gov/pubmed/19105813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-9-625 |
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