Sulindac Derivatives That Activate the Peroxisome Proliferator-activated Receptor γ but Lack Cyclooxygenase Inhibition

[Image: see text] A series of novel derivatives of the nonsteroidal anti-inflammatory drug (NSAID) sulindac sulfide were synthesized as potential agonists of the peroxisome proliferator-activated receptor gamma (PPARγ). Nonpolar and aromatic substitutions on the benzylidene ring as well as retention...

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Main Authors: Felts, Andrew S., Siegel, Brianna S., Young, Shiu M., Moth, Christopher W., Lybrand, Terry P., Dannenberg, Andrew J., Marnett, Lawrence J., Subbaramaiah, Kotha
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2008
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651753/
https://ncbi.nlm.nih.gov/pubmed/18665581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm700969c
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