FGF4 and Retinoic Acid Direct Differentiation of hESCs into PDX1-Expressing Foregut Endoderm in a Time- and Concentration-Dependent Manner

BACKGROUND: Retinoic acid (RA) and fibroblast growth factor 4 (FGF4) signaling control endoderm patterning and pancreas induction/expansion. Based on these findings, RA and FGFs, excluding FGF4, have frequently been used in differentiation protocols to direct differentiation of hESCs into endodermal...

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Библиографические подробности
Главные авторы: Johannesson, Martina, Ståhlberg, Anders, Ameri, Jacqueline, Sand, Fredrik Wolfhagen, Norrman, Karin, Semb, Henrik
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2009
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651644/
https://ncbi.nlm.nih.gov/pubmed/19277121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004794
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