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Phosphatidylinositol 3-kinase/protein kinase Akt negatively regulates plasminogen activator inhibitor type 1 expression in vascular endothelial cells

Plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolytic activity and mediates vascular atherothrombotic disease. Endothelial cells (ECs) synthesize and secrete PAI-1, but the intracellular signaling pathways that regulate PAI-1 expression are not entirely known. We hypothesize that the...

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Autors principals: Mukai, Yasushi, Wang, Chao-Yung, Rikitake, Yoshiyuki, Liao, James K.
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651639/
https://ncbi.nlm.nih.gov/pubmed/17172275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00868.2006
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