Endothelin and sex hormones modulate the fibronectin synthesis by cultured human skin scleroderma fibroblasts

OBJECTIVE: To evaluate the influence of endothelin-1 (ET-1) and sex hormones on cell proliferation and extracellular matrix (ECM) synthesis (ie, fibronectin, laminin) by cultured normal and scleroderma (SSc) human skin fibroblasts (FBs). METHODS: Primary cultures of FBs were treated with ET-1 and se...

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Bibliographic Details
Main Authors: Soldano, S, Montagna, P, Villaggio, B, Parodi, A, Gianotti, G, Sulli, A, Seriolo, B, Secchi, M E, Cutolo, M
Format: Artigo
Language:Inglês
Published: BMJ Publishing Group 2008
Subjects:
Basic and Translational Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651484/
https://ncbi.nlm.nih.gov/pubmed/18952637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2008.097378
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