Use of single-gene reassortant viruses to study the role of avian influenza A virus genes in attenuation of wild-type human influenza A virus for squirrel monkeys and adult human volunteers.

The transfer of six internal RNA segments from the avian influenza A/Mallard/New York/6750/78 (H2N2) virus reproducibly attenuates human influenza A viruses for squirrel monkeys and adult humans. To identify the avian influenza A virus genes that specify the attenuation and host range restriction of...

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Veröffentlicht in:J Clin Microbiol
Hauptverfasser: Clements, M L, Subbarao, E K, Fries, L F, Karron, R A, London, W T, Murphy, B R
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1992
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC265127/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1551982/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jcm.30.3.655-662.1992
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