Massively parallel sequencing identifies the gene Megf8 with ENU-induced mutation causing heterotaxy

Forward genetic screens with ENU (N-ethyl-N-nitrosourea) mutagenesis can facilitate gene discovery, but mutation identification is often difficult. We present the first study in which an ENU- induced mutation was identified by massively parallel DNA sequencing. This mutation causes heterotaxy and co...

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Detalhes bibliográficos
Main Authors: Zhang, Zhen, Alpert, Deanne, Francis, Richard, Chatterjee, Bishwanath, Yu, Qing, Tansey, Terry, Sabol, Steven L., Cui, Cheng, Bai, Yongli, Koriabine, Maxim, Yoshinaga, Yuko, Cheng, Jan-Fang, Chen, Feng, Martin, Joel, Schackwitz, Wendy, Gunn, Teresa M., Kramer, Kenneth L., De Jong, Pieter J., Pennacchio, Len A., Lo, Cecilia W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651267/
https://ncbi.nlm.nih.gov/pubmed/19218456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813400106
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