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Catalytic, Asymmetric α-Fluorination of Acid Chlorides: Dual Metal-Ketene Enolate Activation

[Image: see text] In this Communication, we disclose a catalytic, highly enantioselective (up to >99% ee) α-fluorination of acid chlorides to produce a variety of optically active carboxylic acid derivatives from readily accessible and commercially available starting materials. The reaction depen...

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Detalhes bibliográficos
Main Authors: Paull, Daniel H., Scerba, Michael T., Alden-Danforth, Ethan, Widger, Leland R., Lectka, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651145/
https://ncbi.nlm.nih.gov/pubmed/19049284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja807792c
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