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Phase III, Double-Blind, Randomized Study Comparing Lapatinib Plus Paclitaxel With Placebo Plus Paclitaxel As First-Line Treatment for Metastatic Breast Cancer

PURPOSE: Lapatinib, a dual tyrosine kinase inhibitor of epidermal growth factor receptor (EGFR/ErbB1) and human epidermal growth factor receptor 2 (HER-2/ErbB2), is effective against HER-2–positive locally advanced or metastatic breast cancer (MBC). This phase III trial evaluated the efficacy of lap...

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Dettagli Bibliografici
Autori principali: Di Leo, Angelo, Gomez, Henry L., Aziz, Zeba, Zvirbule, Zanete, Bines, Jose, Arbushites, Michael C., Guerrera, Stephanie F., Koehler, Maria, Oliva, Cristina, Stein, Steven H., Williams, Lisa S., Dering, Judy, Finn, Richard S., Press, Michael F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651098/
https://ncbi.nlm.nih.gov/pubmed/18955454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2008.16.2578
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