Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but not hemichannels, in a dominant negative manner

The connexin (Cx) 50, E48K, mutation is associated with a human dominant congenital cataract; however, the underlying molecular mechanism has not been characterized. The glutamate (E) residue at position 48 is highly conserved across animal species and types of connexins. When expressed in paired Xe...

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Bibliographic Details
Main Authors: Banks, Eric A., Toloue, Masoud M., Shi, Qian, Zhou, Zifei Jade, Liu, Jialu, Nicholson, Bruce J., Jiang, Jean X.
Format: Artigo
Language:Inglês
Published: Company of Biologists 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650834/
https://ncbi.nlm.nih.gov/pubmed/19126675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.034124
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