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CYP2E1 overexpression inhibits microsomal Ca(2+) ATPase activity in HepG2 cells
Cytochrome P450 2E1 (CYP2E1) is a microsomal enzyme that generates reactive oxygen species during its catalytic cycle. We previously found an important role for calcium in CYP2E1-potentiated injury in HepG2 cells. The possibility that CYP2E1 may oxidatively damage and inactivate the microsomal Ca(2+...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2650832/ https://ncbi.nlm.nih.gov/pubmed/19028543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2008.10.020 |
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