Contribution of vraSR and graSR Point Mutations to Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus

We describe here the genetic analysis of a vancomycin-susceptible Staphylococcus aureus (VSSA) strain, Mu50Ω, a strain related to vancomycin-intermediate S. aureus (VISA) strain Mu50. Using a combination of Mu50Ω whole-genome sequencing and genome engineering, we observed a stepwise evolution of van...

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Main Authors: Cui, Longzhu, Neoh, Hui-min, Shoji, Mitsutaka, Hiramatsu, Keiichi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650561/
https://ncbi.nlm.nih.gov/pubmed/19124662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01173-08
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