Perforin-mediated suppression of B-cell lymphoma

In the present study, we have examined the effect of perforin (pfp) deficiency in 4 models of mouse B-cell lymphomagenesis. We have examined pfp loss on the background of either Mlh1 tumor suppressor allele loss or oncogene expression [Ig heavy chain (Eμ)-v-Abl, Eμ-myc, and vav-bcl2]. Pfp was shown...

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Main Authors: Bolitho, Paul, Street, Shayna E. A., Westwood, Jennifer A., Edelmann, Winfried, MacGregor, Duncan, Waring, Paul, Murray, William K., Godfrey, Dale I., Trapani, Joseph A., Johnstone, Ricky W., Smyth, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650333/
https://ncbi.nlm.nih.gov/pubmed/19196996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809008106
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