Activation of the Neuronal Extracellular Signal-Regulated Kinase 2 in the Spinal Cord Dorsal Horn Is Required for Complete Freund's Adjuvant-Induced Pain Hypersensitivity

Extracellular signal-regulated kinase 1 (ERK1) and ERK2 signaling in the spinal cord dorsal horn (SCDH) has been implicated in injury-induced pain hypersensitivity. Available ERK pathway inhibitors cannot distinguish between ERK1 and ERK2, nor can they differentially target the expression of neurona...

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Huvudupphovsmän: Xu, Qinghao, Garraway, Sandra M., Weyerbacher, Amanda R., Shin, Sarah J., Inturrisi, Charles E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2008
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649741/
https://ncbi.nlm.nih.gov/pubmed/19109491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2406-08.2008
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