CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure

Rituximab binds an epitope on the CD20 antigen, encompassed in exon 5 of the MS4A1 gene. We sequenced this region and correlated the presence of mutations with CD20 protein expression and response to R-CHOP in patients with diffuse large B-cell lymphoma: 264 diagnostic biopsies and 15 biopsies taken...

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Detalhes bibliográficos
Main Authors: Johnson, Nathalie A., Leach, Stephen, Woolcock, Bruce, deLeeuw, Ronald J., Bashashati, Ali, Sehn, Laurie H., Connors, Joseph M., Chhanabhai, Mukesh, Brooks-Wilson, Angela, Gascoyne, Randy D.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2009
Assuntos:
Malignant Lymphomas
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649361/
https://ncbi.nlm.nih.gov/pubmed/19211644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.001024
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