CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure

Rituximab binds an epitope on the CD20 antigen, encompassed in exon 5 of the MS4A1 gene. We sequenced this region and correlated the presence of mutations with CD20 protein expression and response to R-CHOP in patients with diffuse large B-cell lymphoma: 264 diagnostic biopsies and 15 biopsies taken...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Johnson, Nathalie A., Leach, Stephen, Woolcock, Bruce, deLeeuw, Ronald J., Bashashati, Ali, Sehn, Laurie H., Connors, Joseph M., Chhanabhai, Mukesh, Brooks-Wilson, Angela, Gascoyne, Randy D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Ferrata Storti Foundation 2009
Gaiak:
Malignant Lymphomas
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649361/
https://ncbi.nlm.nih.gov/pubmed/19211644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2008.001024
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak