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Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

Huntingtin regulates post-Golgi trafficking of secreted proteins. Here, we studied the mechanism by which mutant huntingtin impairs this process. Colocalization studies and Western blot analysis of isolated Golgi membranes showed a reduction of huntingtin in the Golgi apparatus of cells expressing m...

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Detalhes bibliográficos
Main Authors: del Toro, Daniel, Alberch, Jordi, Lázaro-Diéguez, Francisco, Martín-Ibáñez, Raquel, Xifró, Xavier, Egea, Gustavo, Canals, Josep M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649260/
https://ncbi.nlm.nih.gov/pubmed/19144827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-07-0726
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