Folate Deficiency, Hyperhomocysteinemia, Low Urinary Creatinine, and Hypomethylation of Leukocyte DNA Are Risk Factors for Arsenic-Induced Skin Lesions

BACKGROUND: Arsenic methylation relies on folate-dependent one-carbon metabolism and facilitates urinary As elimination. Clinical manifestations of As toxicity vary considerably among individuals and populations, and poor methylation capacity is thought to confer greater susceptibility. OBJECTIVE: A...

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Main Authors: Pilsner, J. Richard, Liu, Xinhua, Ahsan, Habibul, Ilievski, Vesna, Slavkovich, Vesna, Levy, Diane, Factor-Litvak, Pam, Graziano, Joseph H., Gamble, Mary V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649228/
https://ncbi.nlm.nih.gov/pubmed/19270796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.11872
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