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A Non Leaky Artemis-Deficient Mouse that Accurately Models the Human SCID Phenotype Including Resistance to Hematopoietic Stem Cell Transplantation
Two Artemis-deficient (mArt(-/-)) mouse models, independently generated on 129/SvJ backgrounds have the expected T(-)B(-)NK(+)SCID phenotype. However, they fail to mimic the human disease due to CD4(+) T-cell leakiness. Moreover, immune reconstitution in these leaky mouse models following hematopoie...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648806/ https://ncbi.nlm.nih.gov/pubmed/19135937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2008.10.026 |
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