A Non Leaky Artemis-Deficient Mouse that Accurately Models the Human SCID Phenotype Including Resistance to Hematopoietic Stem Cell Transplantation

Two Artemis-deficient (mArt(-/-)) mouse models, independently generated on 129/SvJ backgrounds have the expected T(-)B(-)NK(+)SCID phenotype. However, they fail to mimic the human disease due to CD4(+) T-cell leakiness. Moreover, immune reconstitution in these leaky mouse models following hematopoie...

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Hauptverfasser: Xiao, Zheng, Dunn, Elizabeth, Singh, Kanal, Khan, Imran S., Yannone, Steven M., Cowan, Morton J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648806/
https://ncbi.nlm.nih.gov/pubmed/19135937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2008.10.026
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