Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

The epithelial anion channel CFTR interacts with multiple PDZ domain–containing proteins. Heterologous expression studies have demonstrated that the Na(+)/H(+) exchanger regulatory factors, NHERF1, NHERF2, and PDZK1 (NHERF3), modulate CFTR membrane retention, conductivity, and interactions with othe...

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Main Authors: Singh, Anurag Kumar, Riederer, Brigitte, Krabbenhöft, Anja, Rausch, Brigitte, Bonhagen, Janina, Lehmann, Ulrich, de Jonge, Hugo R., Donowitz, Mark, Yun, Chris, Weinman, Edward J., Kocher, Olivier, Hogema, Boris M., Seidler, Ursula
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2009
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648694/
https://ncbi.nlm.nih.gov/pubmed/19221439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI35541
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