A phosphorylation-acetylation switch regulates STAT1 signaling

Cytokines such as interferons (IFNs) activate signal transducers and activators of transcription (STATs) via phosphorylation. Histone deacetylases (HDACs) and the histone acetyltransferase (HAT) CBP dynamically regulate STAT1 acetylation. Here we show that acetylation of STAT1 counteracts IFN-induce...

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Detalhes bibliográficos
Main Authors: Krämer, Oliver H., Knauer, Shirley K., Greiner, Georg, Jandt, Enrico, Reichardt, Sigrid, Gührs, Karl-Heinz, Stauber, Roland H., Böhmer, Frank D., Heinzel, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2009
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648535/
https://ncbi.nlm.nih.gov/pubmed/19171783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.479209
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