Zic2 regulates the kinetics of neurulation

Mutation in human ZIC2, a zinc finger protein homologous to Drosophila odd-paired, causes holoprosencephaly (HPE), which is a common, severe malformation of the brain in humans. However, the pathogenesis is largely unknown. Here we show that reduced expression (knockdown) of mouse Zic2 causes neurul...

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Autori principali: Nagai, Takeharu, Aruga, Jun, Minowa, Osamu, Sugimoto, Takashi, Ohno, Yoshiki, Noda, Tetsuo, Mikoshiba, Katsuhiko
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2000
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC26484/
https://ncbi.nlm.nih.gov/pubmed/10677508
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