Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

BACKGROUND: In a transgenic mouse model of Alzheimer disease (AD), cleavage of the amyloid precursor protein (APP) by the α-secretase ADAM10 prevented amyloid plaque formation, and alleviated cognitive deficits. Furthermore, ADAM10 overexpression increased the cortical synaptogenesis. These results...

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Autors principals: Prinzen, Claudia, Trümbach, Dietrich, Wurst, Wolfgang, Endres, Kristina, Postina, Rolf, Fahrenholz, Falk
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647556/
https://ncbi.nlm.nih.gov/pubmed/19196476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-10-66
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