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A designed RNA selection: establishment of a stable complex between a target and selectant RNA via two coordinated interactions
In this paper, we describe a new method for selecting RNA aptamers that cooperatively bind to two specific sites within a target RNA. We designed a selection system in which two RNAs, a target RNA and a RNA pool, were assembled by employing a pre-organized GAAA tetraloop-11-nt receptor interaction....
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2647284/ https://ncbi.nlm.nih.gov/pubmed/19136470 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn1012 |
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