Maximizing the Renal Cyclic 3′-5′-Guanosine Monophosphate System with Type V Phosphodiesterase Inhibition and Exogenous Natriuretic Peptide: A Novel Strategy to Improve Renal Function in Experimental Overt Heart Failure

Type V phosphodiesterase (PDE V) metabolizes cyclic guanosine monophosphate (cGMP) and is abundant in the kidney and vasculature and was found recently in the heart. Sildenafil is a PDE V inhibitor that is used clinically for erectile dysfunction. Brain natriuretic peptide (BNP) is a cardiac peptide...

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Hlavní autoři: Chen, Horng H., Huntley, Brenda K., Schirger, John A., Cataliotti, Alessandro, Burnett, John C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647144/
https://ncbi.nlm.nih.gov/pubmed/16928803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2006020161
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