The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role In the Development of Liver Stage Malarial Parasites

Fatty acid biosynthesis has been viewed as an important biological function of and therapeutic target for Plasmodium falciparum asexual blood stage infection. This apicoplast-resident type II pathway, distinct from the mammalian type I process, includes FabI. Here, we report synthetic chemistry and...

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Main Authors: Yu, Min, Santha Kumar, T. R., Nkrumah, Louis J., Coppi, Alida, Retzlaff, Silke, Li, Celeste D., Kelly, Brendan J., Moura, Pedro A., Lakshmanan, Viswanathan, Freundlich, Joel S., Valderramos, Juan-Carlos, Vilcheze, Catherine, Siedner, Mark, Tsai, Jennifer H.-C., Falkard, Brie, Sidhu, Amar bir Singh, Purcell, Lisa A., Gratraud, Paul, Kremer, Laurent, Waters, Andy P., Schiehser, Guy, Jacobus, David P., Janse, Chris J., Ager, Arba, Jacobs, William R., Sacchettini, James C., Heussler, Volker, Sinnis, Photini, Fidock, David A.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2008
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646117/
https://ncbi.nlm.nih.gov/pubmed/19064257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2008.11.001
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