Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors

Acting through a number of distinct pathways, many G protein-coupled receptors (GPCRs) activate the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) cascade. Recently, it has been shown that in some cases, clathrin-mediated endocytosis is required for GPCR activati...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Pierce, Kristen L., Maudsley, Stuart, Daaka, Yehia, Luttrell, Louis M., Lefkowitz, Robert J.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2000
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26461/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10677489/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.4.1489
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