Reduced Adipose Tissue Oxygenation in Human Obesity: Evidence for Rarefaction, Macrophage Chemotaxis, and Inflammation Without an Angiogenic Response

OBJECTIVE— Based on rodent studies, we examined the hypothesis that increased adipose tissue (AT) mass in obesity without an adequate support of vascularization might lead to hypoxia, macrophage infiltration, and inflammation. RESEARCH DESIGN AND METHODS— Oxygen partial pressure (AT pO(2)) and AT te...

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Detalhes bibliográficos
Main Authors: Pasarica, Magdalena, Sereda, Olga R., Redman, Leanne M., Albarado, Diana C., Hymel, David T., Roan, Laura E., Rood, Jennifer C., Burk, David H., Smith, Steven R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
Assuntos:
Pathophysiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646071/
https://ncbi.nlm.nih.gov/pubmed/19074987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1098
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