Dipeptidyl Peptidase IV Inhibition With MK0431 Improves Islet Graft Survival in Diabetic NOD Mice Partially via T-Cell Modulation

OBJECTIVE—The endopeptidase dipeptidyl peptidase-IV (DPP-IV) has been shown to NH(2)-terminally truncate incretin hormones, glucose-dependent insulinotropic polypeptide, and glucagon-like peptide-1, thus ablating their ability to potentiate glucose-stimulated insulin secretion. Increasing the circul...

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Bibliografiske detaljer
Main Authors: Kim, Su-Jin, Nian, Cuilan, Doudet, Doris J., McIntosh, Christopher H.S.
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2009
Fag:
Immunology and Transplantation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646063/
https://ncbi.nlm.nih.gov/pubmed/19073764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db08-1101
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