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Reduced neuronal co-localisation of nardilysin and the putative α-secretases ADAM10 and ADAM17 in Alzheimer’s disease and Down syndrome brains
The peptidase nardilysin is involved in degradation of neuropeptides and limited intracellular proteolysis. Recent reports point to an involvement of nardilysin in the pathophysiology of Alzheimer’s disease. Nardilysin enhances the α-secretase activity of the disintegrin and metalloproteases (ADAMs)...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Netherlands
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645990/ https://ncbi.nlm.nih.gov/pubmed/19234765 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-008-9076-x |
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