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Oxo-ester Mediated Native Chemical Ligation: Concept and Applications
[Image: see text] A direct oxo-ester peptide ligation method has been developed. Through the use of an activated C-terminal para-nitrophenyl ester (cf. 1), it is possible to achieve direct cysteine ligations (1 +2 → 4). Peptide substrates incorporating bulky C-terminal amino acids (cf. 1, R) can be...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2645925/ https://ncbi.nlm.nih.gov/pubmed/18855357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804993y |
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