Dynamic Regulation of Alternative Splicing by Silencers that Modulate 5′ Splice Site Competition

Alternative splicing makes a major contribution to proteomic diversity in higher eukaryotes with ~70% of genes encoding two or more isoforms. In most cases, the molecular mechanisms responsible for splice site choice remain poorly understood. Here, we used a randomization-selection approach in vitro...

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Main Authors: Yu, Yang, Maroney, Patricia A., Denker, John A., Zhang, Xiang H-F., Dybkov, Olexandr, Lührmann, Reinhard, Jankowsky, Eckhard, Chasin, Lawrence A., Nilsen, Timothy W.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645801/
https://ncbi.nlm.nih.gov/pubmed/19109894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2008.10.046
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