Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death

BACKGROUND: Disturbed cellular cholesterol homeostasis may lead to accumulation of cholesterol in human atheroma plaques. Cellular cholesterol homeostasis is controlled by the sterol regulatory element-binding transcription factor 2 (SREBF-2) and the SREBF cleavage-activating protein (SCAP). We inve...

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Bibliographic Details
Main Authors: Fan, Yue-Mei, Karhunen, Pekka J, Levula, Mari, Ilveskoski, Erkki, Mikkelsson, Jussi, Kajander, Olli A, Järvinen, Otso, Oksala, Niku, Thusberg, Janita, Vihinen, Mauno, Salenius, Juha-Pekka, Kytömäki, Leena, Soini, Juhani T, Laaksonen, Reijo, Lehtimäki, Terho
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Original Clinical Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645360/
https://ncbi.nlm.nih.gov/pubmed/19116028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-9560-6-17
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