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In Vivo and In Vitro Alterations in Influenza A/H3N2 Virus M2 and Hemagglutinin Genes: Effect of Passage in MDCK-SIAT1 Cells and Conventional MDCK Cells

No mutations were detected in the hemagglutinin gene of influenza A/H3N2 virus isolates from patients undergoing short-term amantadine treatment. However, genetic changes occurred after serial passage in either MDCK or MDCK-SIAT1 cells. Our results showed that only a few mutations were observed in M...

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Detalhes bibliográficos
Main Authors: Li, Danjuan, Saito, Reiko, Suzuki, Yasushi, Sato, Isamu, Zaraket, Hassan, Dapat, Clyde, Caperig-Dapat, Isolde Ma, Suzuki, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643669/
https://ncbi.nlm.nih.gov/pubmed/19091815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00892-08
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