L-DOPA Neurotoxicity Is Mediated by Up-Regulation of DMT1−IRE Expression

BACKGROUND: The mechanisms underlying neurotoxicity caused by L-DOPA are not yet completely known. Based on recent findings, we speculated that the increased expression of divalent metal transporter 1 without iron-response element (DMT1−IRE) induced by L-DOPA might play a critical role in the develo...

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Bibliographic Details
Main Authors: Du, Fang, Qian, Zhong-ming, Zhu, Li, Wu, Xiao Mei, Yung, Wing-ho, Tsim, Ting-yuk, Ke, Ya
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643485/
https://ncbi.nlm.nih.gov/pubmed/19240805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004593
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