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Overload of the heat shock protein H11/HspB8 triggers melanoma cell apoptosis through activation of Transforming Growth Factor β activated kinase 1 (TAK1)
Molecular therapeutics is a recognized promising approach for melanoma, but relevant target genes remain elusive. We report that overload of the recently cloned H11/HspB8 induces apoptosis in 55% of examined melanoma cultures. Apoptosis was determined by activation of caspases-9 and -3 and TUNEL, an...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2643355/ https://ncbi.nlm.nih.gov/pubmed/17173073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210145 |
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