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A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight

We have developed a physiologically-based mathematical model, with parameters derived from published experimental data, to simulate the regulatory effects of the leptin pathway on murine energy homeostasis. Model outcomes are consistent with data reported in the literature, and reproduce key charact...

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Detalhes bibliográficos
Main Authors: Tam, Joshua, Fukumura, Dai, Jain, Rakesh K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643084/
https://ncbi.nlm.nih.gov/pubmed/19117546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.11.005
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